In Europe, where the study of natural medicines is much more advanced than in the U.S. there is a German Kommission E Monograph regarding Melissa, attesting to its clinical uses in nervous disturbance of sleep, functional gastrointestinal disorders, and as an appetite stimulant for those needing it. Further studies with Melissa have revealed strong antiviral properties, especially with regard to herpes virus in a topical application. Long celebrated for its benefits with hyperactivity in children, Melissa, when combined with other similar sedative herbs according to the German Kommission E may be advantageous.